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. 2017 Sep 12;7:11306. doi: 10.1038/s41598-017-11751-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AZD4547 induces histoarchitectural and proliferative downregulation in premalignant mammary glands from MMTV-ErbB2 mice. 8-week-old MMTV-ErbB2 mice were administered AZD4547 (0, 2, or 6 mg/kg/day) for 10 weeks. Then mammary glands were excised for whole mount and histological analyses. Representative images of mammary gland whole mounts are shown in (a). Ductal branching complexity (the number of side branches in a 10 mm² field, (b) was analyzed from the whole mounts. Four 10 mm² fields were analyzed per sample to determine the branching densities. Mammary glands were also collected after AZD4547 treatments and processed for FFPE. The FFPE tissues were H&E stained (c) or processed for IHC staining of Ki67 (d). The percentages of Ki67⁺ cells are graphed below the panels of representative Ki67-stained tissues. All values are presented as the mean ± S.E. (^** P ≤ 0.01).