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. 2017 Sep 12;7:11306. doi: 10.1038/s41598-017-11751-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AZD4547 suppresses luminal and MaSC populations in primary MECs from MMTV-ErbB2 mice. Primary MECs were isolated from 18-week-old mice that were treated with AZD4547 (0, 2, or 6 mg/kg/day) for 10 weeks. (a) MECs were sorted based on CD24/CD49f expression and the cells formed distinct cell populations of luminal, MRU, and myoepithelial cells. (b) The average percentages of cells in the luminal (left panel), MRU (middle panel), and myoepithelial (right panel) subpopulations are graphed. All values are presented as the mean ± S.E. (^* P ≤ 0.05, ^** P ≤ 0.01).