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. 2017 Sep 12;7:11306. doi: 10.1038/s41598-017-11751-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AZD4547 treatment reduces stemness in spontaneous tumors from MMTV-ErbB2 mice. MMTV-ErbB2 mice with spontaneous mammary tumors were treated with AZD4547 (0 or 6 mg/kg/day) for 3 weeks. (a) Tumors were excised and primary tumor cells were isolated for an ALDEFLUOR assay of ALDH activity. Representative plots of the ALDH⁺ cell gating are found in the left and middle panels. The percentages of ALDH⁺ cells are graphed in the right panel. (b) Primary tumor cells were subjected to a primary tumorsphere assay for 7 days. Then, tumorspheres were imaged and counted. (c) Primary tumor cells were also grown in matrigel for a 3D culture assay. The numbers of colonies formed after 7 days are graphed. All values are presented as the mean ± S.E. (^* P ≤ 0.05, ^** P ≤ 0.01).