Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 12;7:11255. doi: 10.1038/s41598-017-11483-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Deactivation/activation pathways of morphine-bound and TRV-130-bound MOR systems. Transition path theory-predicted pathways with more than 1% of the flux linking (a) the active-like kinetic macrostate #11 and the inactive-like macrostate #12 of morphine-bound MOR, and (b) the active-like macrostate #9 and the inactive-like macrostate #12 of TRV-130-bound MOR. Arrow thickness is proportional to the net fluxes between two kinetic macrostates. Macrostates are represented as circles of size proportional to their equilibrium probability and are color-coded as in Fig. 1. Numbers next to each arrow represent the mean first passage time (in units of µs) to go from one macrostate to the other in the direction of the arrows (black) or in the reverse direction (gray). First and third quartiles are indicated as superscript and subscript, respectively. Dotted lines in panel (a) connect alternative inactive macrostates #9 and #13 that can be reached from the active state only from macrostate #12.