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. 2017 Sep 12;7:11408. doi: 10.1038/s41598-017-11628-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of DXN on Aβ deposits or Aβ oligomers in AD worms. (A) ThS staining images of Aβ deposits in unc-54/human Aβ_1-42 worms after treatment with or without 15 mg/mL DXN, and 10 mM memantine (MEM) was used as positive control. Wild type N2 was used as ThS Aβ-specific staining control. The scale bar was 20 μm. Data are the average of three replicates with about 24 worms in each group. (B) Quantification of ThS-positive particles in head region of unc-54/human Aβ_1-42 worms. There is significant difference among these groups when symbols are different (P < 0.05). (C) Western blot of Aβ species in the temperature sensitive Aβ strain CL4176 treated with or without 15 mg/mL DXN. (D) Band intensity of 4 KD Aβ monomers or 20 KD oligomers in C were analyzed by Image J software. Data are the average of three replicates with about 400–500 worms in each group.