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. 2017 Sep 12;7:11406. doi: 10.1038/s41598-017-11784-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Death receptor-induced cell death and endoplasmic reticulum stress. (A) Caspase 8 activity measured using ELISA, and RIP 1 and 3 expression examined through western blotting. (B) Caspase 12 activity measured using ELISA, and CHOP and ATF-4 expression analyzed through western blotting. The uncropped western blot images are shown in Fig. S3. Data are expressed as the means ± SD of 3 independent experiments for the caspase 12 assay, and 4 independent experiments for all other assays. *P < 0.05 and **P < 0.01 versus the negative control.