Table 1.
Approved drugs with six or more patterns.
| Drug name | Target | Disease | Scaffold | N Patterns |
|---|---|---|---|---|
| Adenosine | Uridine 5′-nucleotidase | Myocardial perfusion scintigraphy and help identify coronary artery disease. | Nucleobases | 8 |
| Cladribine | Deoxycytidine kinase | Hairy cell leukemia | Nucleobases | 7 |
| Folic acid | Folate receptor alpha | Folate deficiencies and megaloblastic anemia. | Aminopteridones | 7 |
| Tetrahydrobiopterin | Nitric oxide synthase | Phenylketonuria(PKU) | Aminopteridones | 7 |
| Amodiaquine | Histamine N-methyltransferase | Acute malaria attacks in non-immune subjects | Singletons | 6 |
| Mercaptopurine | Xanthine dehydrogenase/oxidase | Lymphatic Leukemia | Nucleobases | 6 |
| Pentostatin | Adenosine deaminase | Lymphoproliferative malignancies, particularly hairy-cell leukemia | Nucleobases | 6 |
| Pentoxifylline | Chitinase | Peripheral vascular diseases and cerebrovascular insufficiency. | Nucleobases | 6 |
| Pyridoxal Phosphate | D-serine dehydratase | Dietary shortage or imbalance. | Singletons | 6 |
| Quercetin | Xanthine dehydrogenase/oxidase | Dicrease capillary fragility. | Flavones | 6 |
| Telbivudine | Deoxycytidine kinase | HepatitisB virus (HBV) | Nucleobases | 6 |
| Triamterene | Pteridine reductase 1 | Edema associated with congestive heart failure. | Aminopteridones | 6 |
Listed are the drugs and their targets as well as their original indication and chemical class.