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. 2017 Sep 12;7:11258. doi: 10.1038/s41598-017-11638-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network depicting downregulated miRs that have been identified as putative key regulatory miRs based on the differential expression of their predicted mRNA targets (miRhubs analysis), and their upregulated DE predicted targets. Consensus DE miRs that are predicted to regulate many DE mRNAs are depicted as purple diamonds. Mmu-miR-126-3p which is a consensus DE miR predicted to target 8 DE mRNAs is depicted as a gray oblong. Downregulated miRs that are identified as putative hubs but that are not DE by the filtering criteria (miR-mmu-let-7a-5p, mmu-miR-23a-5p, mmu-miR-23a-3p, mmu-miR-205-5p) are also depicted as gray oblongs. DE mRNAs that are upregulated during pneumonia are colored red. Gray lines connect miRs with their predicted target DE mRNAs.