Table 1.
Top 25 molecular pathways significantly enriched in lung neutrophils from mice given PBS or S. pneumoniae.
| Gene sets enriched in S. pneumoniae samples | Gene sets enriched in PBS samples |
|---|---|
| (GO:0035456) response to interferon-beta | (GO:0042384) cilium assembly |
| (GO:0002237) response to molecule of bacterial origin | (GO:0044782) cilium organization |
| (GO:0032496) response to lipopolysaccharide | (GO:0060271) cilium morphogenesis |
| (GO:0071219) cellular response to molecule of bacterial origin | (GO:0001578) microtubule bundle formation |
| (GO:0071222) cellular response to lipopolysaccharide | (GO:0003341) cilium movement |
| (GO:0071216) cellular response to biotic stimulus | (GO:0035082) axoneme assembly |
| (GO:0035458) cellular response to interferon-beta | (GO:0010927) cellular component assembly involved in morphogenesis |
| (GO:0032655) regulation of interleukin-12 production | (GO:0030031) cell projection assembly |
| (GO:0034097) response to cytokine | (GO:0007018) microtubule-based movement |
| (GO:0001819) positive regulation of cytokine production | (GO:0007224) smoothened signaling pathway |
| (GO:0032615) interleukin-12 production | (GO:0007368) determination of left/right symmetry |
| (GO:0042832) defense response to protozoan | (GO:0070286) axonemal dynein complex assembly |
| (GO:0045088) regulation of innate immune response | (GO:0042073) intraciliary transport |
| (GO:0045087) innate immune response | (GO:0021532) neural tube patterning |
| (GO:0034341) response to interferon-gamma | (GO:0021904) dorsal/ventral neural tube patterning |
| (GO:0045089) positive regulation of innate immune response | (GO:0009799) specification of symmetry |
| (GO:0071345) cellular response to cytokine stimulus | (GO:0009855) determination of bilateral symmetry |
| (GO:0019882) antigen processing and presentation | (GO:0048858) cell projection morphogenesis |
| (GO:0031349) positive regulation of defense response | (GO:0008589) regulation of smoothened signaling pathway |
| (GO:0032649) regulation of interferon-gamma production | (GO:0003351) epithelial cilium movement |
| (GO:0002675) positive regulation of acute inflammatory response | (GO:0032990) cell part morphogenesis |
| (GO:0019221) cytokine-mediated signaling pathway | (GO:0021591) ventricular system development |
| (GO:0032609) interferon-gamma production | (GO:0007017) microtubule-based process |
| (GO:0009617) response to bacterium | (GO:0009062) fatty acid catabolic process |
| (GO:0001562) response to protozoan | (GO:0036158) outer dynein arm assembly |
Gene Set Enrichment Analysis (GSEA) was done using gene sets from the Molecular Signatures Database (http://www.broadinstitute.org/gsea/index.jsp). FDR < 0.00005.