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. 2017 Sep 12;8:417. doi: 10.1038/s41467-017-00462-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Phase misalignment disrupts rhythmic gene expression in a pathways and tissue-specific manner. Transcript profiles of major clock-controlled regulator genes of cell cycle (Wee1), epigenetic regulation (Ezh2), metabolism (Pparγ), oxidative stress (Nrf2) and inflammation (RelA) from mice housed in 24 or 22.5 h conditions for 17 weeks. All data plotted mean ± SEM relative to the respective light cycle (24 or 22.5 h) and normalised to ZT0 of the 24 h LD group (n = 4/time-point/group). ^∗Significant (p < 0.05) difference in phase between 24 and 22.5 h profiles; a = significant difference in amplitude or mesor between 24 and 22.5 h LD conditions (sinusoidal waveform fits with F tests for shared characteristics)