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. 2017 Sep 12;7:11277. doi: 10.1038/s41598-017-11842-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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OA inhibited the growth of CAL27 xenograft tumors in nude mice. CAL27 xenograft tumors were treated with OA (2 or 4 mg/kg, i.p, every two days) or (0.2 ml saline as control) for 14 times, and the animals were euthanized on day 40. (a) Representative photographs of the gross tumors from nude mice. (b) Graphs represent the average tumor volumes of CAL27 xenografts in mice from the control and OA-treated groups. (c) Graphs represent the average weights of tumors from the control and OA-treated groups (*p < 0.05, **p < 0.01). (d) The expression of p-Akt, p-mTOR, p-S6K, and the cleavage of caspase-3 was detected by immunohistochemical staining and the expression of p-Akt, p-mTOR, and p-S6K was decreased and cleaved-caspase-3 expression was induced after OA treatment.