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. 2017 Sep 12;7:11344. doi: 10.1038/s41598-017-10297-y

Figure 1.

Figure 1

Genetically encoded protein scaffolds with modular biochemical and magnetic functions. (a,b) Schematic of the modular approach to functionalize and organize ferritin nanocages. (a) Chemically inducible dimerization strategy based on the heterodimerization of FKBP and FRB is used to target a protein of interest (POI) at the surface of the ferritin nanocages by addition of Rapamycin. (b) The formation of ferritin clusters is triggered by multimeric interactions between FKBP- and FRB-ferritins in presence of Rapamycin. (c) Illustration of the functionalization and magnetic manipulation of biomineralised ferritin clusters to control a microtubule assembly in space and time.