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. 2017 Sep 12;7:11344. doi: 10.1038/s41598-017-10297-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterisation and magnetic manipulation of biomineralised ferritins. (a,b) TEM images of mineralized FRB-ferritins and ferritin clusters (negative staining). Monodisperse iron oxide nanoparticles are shown in (a). The addition of Rapamycin and FKBP-ferritins into the FRB-ferritin solution causes the assembly of proteins nanocages to form micrometer-sized structures (b). (c,d) Fluorescence images of mineralized FRB-ferritins and ferritin clusters. The nanocages were labelled with FKBP-mCherry for fluorescence visualization within droplets of water dispersed within mineral oil (see schematic). Magnetic forces were induced by (c) a magnetic tip for focusing the gradient of forces, or (d) a permanent magnet for a long-range attraction of the clusters. (e) Mean fluorescence intensity as a function of time at the vicinity of the magnetic tip showing the local recruitment of single ferritins.