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. 2017 Sep 12;7:11289. doi: 10.1038/s41598-017-10637-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Trem2 ^−/− mice are protected against LCMV-induced hepatitis. WT and Trem2 ^−/− mice were infected with LCMV strain WE. (A) Body weight was monitored after LCMV infection (n = 5 mice per group, representative of ≥ two independent experiments). (B,C) Serum kinetics of alanine aminotransferase (ALT) (B) and aspartate aminotransferase (AST) (C) were measured after LCMV infection (n = 5 mice per group, representative of ≥ two independent experiments). (D,E) Serum levels of alkaline phosphatase (AP) (D) and bilirubin (E) were measured eight and ten days post infection (n = 5 mice per group, representative of two independent experiments). (F) Liver sections of infected WT and Trem2 ^−/− were histopathologically scored (see Methods; n = 5 mice per group). (G) Liver sections of infected WT and Trem2 ^−/− were stained for cleaved Caspase 3 and the number of positive cells in 10 fields was quantified (n = 4 mice per group). Statistical significance was calculated by (A–E) Two-way ANOVA with Bonferroni correction or by (F,G) unpaired t-test. Symbols respectively bars represent the mean ± SEM.