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. 2017 Sep 12;7:11289. doi: 10.1038/s41598-017-10637-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Non-hematopoietic TREM2 aggravates LCMV-induced hepatitis. (A–G) Chimeric mice were generated by reciprocal transfer of WT and Trem2 ^−/− bone marrow and subsequently infected with LCMV strain WE. (A,B) Serum kinetics of alanine aminotransferase (ALT) (A) and aspartate aminotransferase (AST) (B) were measured after LCMV infection (n = 8–9 mice per group, data pooled from two similar experiments). (C,D) Serum levels of alkaline phosphatase (AP) (C) and bilirubin (D) were measured ten days post infection (n = 8–9 mice per group, data pooled from two similar experiments). (E–G) Liver sections from infected mice were stained for LCMV nucleoprotein. Representative images are shown in (E) and LCMV⁺ hepatocytes and Kupffer cells were quantified (F,G) (n = 8–9 mice per group, data pooled from two similar experiments harvested at 10 respectively 12 days post infection). Scale bar represents 50 μM. Statistical significance was calculated by (A–D) Two-way or by (F,G) One-way ANOVA with Bonferroni correction. Symbols respectively bars represent the mean ± SEM.