Table 1.
Identification of PB2-701 and 702 mutants isolated in mammalian and avian hosts.
| PB2-701/702 | ||
|---|---|---|
| A/A (5.7%) | H/G (0.9%) | S/A (7.5%) |
| A/E (0.9%) | H/P (4.7%) | S/C 0.9%) |
| A/K (3.8%) | H/R (5.7%) | S/E (0.9%) |
| A/S (9.4%) | M/P (4.7%) | S/F (0.9%) |
| C/G (1.9%) | N/G (5.7%) | S/L (2.8%) |
| C/T (0.9%) | N/V (0.9%) | S/P (3.8%) |
| D/G# (1.9%) | N/W (1.9%) | S/R (0.9%) |
| D/I^ (3.8%) | Q/Q (2.8%) | S/S (1.9%) |
| D/K* (2.8%) | Q/V (0.9%) | T/P (3.8%) |
| E/R¶ (10.4%) | R/P (3.8%) | V/S (0.9%) |
| E/A (1.9%) | ||
Total no. of mutants: 31.
Percentages in brackets indicate the relative frequency of mutants isolated from a total of 106 plaque purified clones.
*Wild type A/Puerto Rico/8/1934.
^Same residues 701 and 702 as A/New York/389/2005 2005/01/04, A/ruddy shelduck/Mongolia/686C2/2008(H2N3).
#Same residues 701 and 702 as A/duck/Hunan/S11547/2012(H4N9), A/England/558/2003(H3N2), A/TW/229/03(H3N2).
¶Same residues 701 and 702 as A/Port Chalmers/1/1973(H3N2), A/England/534/2003(H3N2).