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. 2017 Sep 12;7:11338. doi: 10.1038/s41598-017-11092-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HPLC-MS in Resistant and Susceptible DGRP Subsets. The amount of Imidacloprid (A,D), IMI-5-OH (B,E) and IMI-Olefin (C,F) recovered from larval bodies (A–C) or the media (D–F) is reported in parts per billion (ppb) from a subset of the most susceptible (blue) and resistant (red) DGRP lines. No data is presented for imidacloprid in the media, due to the relative abundance of this molecule in the media, which makes detecting changes impossible. Error bars represent standard error of the mean. Stars represent the significance of association of each phenotype with RMR among genotypes using Pearson’s correlation test (*p < 0.05; **p < 0.001; ***p < 0.0001).