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. 2017 Sep 12;7:11392. doi: 10.1038/s41598-017-11892-9

Table 2.

Selected genes whose transcription is down-regulated by PAßN.

PA numbera Gene namea Fold changeb Product namea
PA0672∫ hemO −4.81 hemeoxygenase
PA0676∫ vreR −4.85 sigma factor regulator, VreR
PA0707 toxR −2.12 transcriptional regulator ToxR
PA1245 aprX −3.44 AprX
PA1912∫ femI −2.35 ECF sigma factor, FemI
PA2385∫ pvdQ −2.98 3OC12-homoserine lactone acylasePvdQ
PA2386∫ pvdA −3.97 L-ornithine N 5-oxygenase
PA2394∫ pvdN −2.85 PvdN
PA2395∫ pvdO −2.32 PvdO
PA2396∫ pvdF −3.22 pyoverdinesynthetase F
PA2397∫ pvdE −3.16 pyoverdine biosynthesis protein PvdE
PA2398∫ fpvA −2.03 ferripyoverdine receptor
PA2399∫ pvdD −3.32 pyoverdinesynthetase D
PA2400∫ pvdJ −3.36 PvdJ
PA2413∫ pvdH −3.58 l-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase
PA2424∫ pvdL −3.73 PvdL
PA2425∫ pvdG −2.58 PvdG
PA2426∫ pvdS −10.48 sigma factor PvdS
PA2570 lecA −2.42 LecA
PA3377◊ phnJ −21.1 conserved hypothetical protein
PA3407∫ hasAp −4.15 heme acquisition protein HasAp
PA3530∫ bfd −2.54 bacterioferritin-associated ferredoxinBfd
PA4221∫ fptA −2.52 Fe(III)-pyochelin outer membrane receptor precursor
PA4224∫ pchG −2.05 pyochelin biosynthetic protein PchG
PA4225∫ pchF −2.26 pyochelinsynthetase
PA4226∫ pchE −2.06 dihydroaeruginoic acid synthetase
PA4228∫ pchD −2.09 pyochelin biosynthesis protein PchD
PA4230∫ pchB −2.69 salicylate biosynthesis protein PchB
PA4468 sodM −11.65 superoxide dismutase
PA4470 fumC1 −8.96 fumaratehydratase
PA4708∫ phuT −3.17 heme-transport protein, PhuT
PA4709∫ phuS −3.37 PhuS
PA4710∫ phuR −4.65 heme/hemoglobin uptake outer membrane receptor PhuR
PA5360◊ phoB −15.28 two-component response regulator PhoB
PA5365◊ phoU −9.4 phosphate uptake regulatory protein PhoU
PA5366◊ pstB −14.02 ATP-binding component of ABC phosphate transporter
PA5367◊ pstA −14.17 membrane protein component of ABC phosphate transporter
PA5369◊ pstS −23.49 periplasmic phosphate-binding protein, PstS

aPA number, gene name and product name are from the Pseudomonas GenomeDatabase23. Genes previously reported as controlled by 3OC12-HSL are in bold characters36–38. ∫Genes previously reported to be controlled by iron starvation25; ◊Genes previously reported to be controlled by phosphate starvation27.

bFold change in gene expression in P. aeruginosa PAO1 grown in LB supplemented with 27 µM PAßN with respect to the same strain grown in LB.