Table 1.
Animal data of control mice, and wild-type and HIF-2α transgenic CKD mice at 2 weeks and 4 weeks.
| Parameters | Control | At 2 weeks | At 4 weeks | |||
|---|---|---|---|---|---|---|
| WT | Tg | WT | Tg (DOX at D0) | Tg (DOX at D14) | ||
| Body Weight (g) | 26.7 ± 1.1 | 23.5 ± 0.9 | 22.3 ± 0.8* | 23.5 ± 1.3 | 21.3 ± 0.8* | 20.9 ± 1.0** |
| BUN (mg/dL) | 28.3 ± 1.6 | 85.6 ± 11.4*** | 74.3 ± 5.6*** | 102.9 ± 8.7*** | 91.9 ± 7.5*** | 73.0 ± 7.5***, ## |
| Serum creatinine (mg/dL) | 0.25 ± 0.01 | 0.61 ± 0.07*** | 0.56 ± 0.05*** | 0.79 ± 0.05***, †† | 0.71 ± 0.05*** | 0.63 ± 0.02***, # |
CKD, chronic kidney disease; BUN, blood urea nitrogen; WT, wild-type; Tg, transgenic; DOX, doxycycline.
*P < 0.05, **P < 0.01, and ***P < 0.001, and vs. controls; # P < 0.05, and ## P < 0.01 vs. WT mice at 4 weeks; †† P < 0.01 vs. WT mice at 2 weeks.