Table 3.
Serological and histological features of pSS in male studies
| References | Positive biopsy N (%) | Anti-SSA N (%) | Anti-SSB N (%) | ANA N (%) | RF N (%) | Cryoglobulinaemia N (%) | Other N (%) |
|---|---|---|---|---|---|---|---|
| Molina et al. [16] | 29/31 (93.5)a | 7 (19.4) | 2 (5.6) | 19 (52.8) | 8 (22.2) | – | Raised Ig—7 (19.4) |
| Anaya et al. [17] | – | 8 (61.5) | 6 (46.2) | 11 (84.6) | 8/11 (72.7) | 1/9 (11.1) | Lymphopenia—5 (38.5) |
| Neutropenia—1 (7.7) | |||||||
| Horvath et al. [18] | – | 45 (75.0) | 31 (51.7) | 22 (36.7) | 16 (26.7) | 4 (6.7) | Other ENA—37 (61.6) |
| Anti-CCP—9 (15.0) | |||||||
| dsDNA—4 (6.7) | |||||||
| Anti-thyroglobulin—1 (1.7) | |||||||
| Anti-TPO—1 (1.7) | |||||||
| Gondran et al. [19] | 42 (100)b | 21 (50.0) | 14 (33.3) | 32 (76.2) | 22 (52.4) | 8 (19.0) | Raised Ig—20 (47.6) |
| Thrombocytopenia—9 (21.4) | |||||||
| Lymphopenia—3 (7.1) | |||||||
| Leukopenia—1 (2.4) | |||||||
| Cervera et al. [20] | – | 3 (15.8) | 3 (15.8) | 13 (68.4) | 5 (26.3) | 1/14 (7.1) | Hypocomplementaemia—0/16 (0.0) |
| Diaz-Lopez et al. [21] | – | 7 (25.0) | 4 (14.3) | 22 (78.6) | 13 (46.4) | – | Raised IgA—11 (39.2) |
| Raised IgG—7 (25.0) | |||||||
| Raised IgM—2 (7.1) | |||||||
| Anti-thyroid—2 (7.1) | |||||||
| Low IgM—1 (3.5) | |||||||
| Drosos et al. [22] | – | 2 (16.7) | 1 (8.3) | 4 (33.3) | 8 (66.7) | – | – |
ANA anti-nuclear antibody, Anti-CCP anti-cyclic citrullinated peptide, Anti-TPO anti-thyroid peroxidase, dsDNA double stranded DNA, ENA extractable nuclear antigen, Ig immunoglobulin, TPO thyroperoxidase, RF rheumatoid factor
aGrade III/IV Greenspan Criteria
bCriteria unknown