Table 4.
Serological and histological features of pSS in paediatric studies
| References | Abnormal sialometry N (%) | Abnormal salivary scintigraphy N (%) | Abnormal ocular stain N (%) | Positive biopsy N (%) | Positive sialography N (%) | Anti-SSA N (%) | Anti-SSB N (%) | Anti-SSA and/or anti-SSB N (%) | Anti-ENA N (%) | ANA N (%) | RF N (%) | Raised ESR N (%) | Raised IgG N (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yokogowa et al. [23] | 5/7 (71.4)a | 3/3 (100) | 4/16 (25.0) | 10/15 (66.7)b 15/15 (100)c | – | 22/26 (84.6) | 17/26 (65.4) | 22 (84.6) | – | 25 (96.2) | 16 (72.7) | – | – |
| Cimaz et al. [24] | – | 30 (75.0) | – | 40 (100)d | 40 (100) | – | – | – | 29 (72.5) | 34 (85.0) | 30 (75.0) | 27 (67.5) | 21 (52.5) |
| Drosos et al. [22] | – | – | – | – | – | 7 (53.8) | 4 (30.8) | 11 (84.6) | 11 (84.6) | 9 (69.2) | 6 (46.2) | – | – |
| Stiller et al. [25] | 9 (81.8)e | – | 8 (72.7) | 10 (90.9)d | 10 (90.9) | 4 (36.4) | 3 (27.3) | 7 (63.6) | – | 7 (63.6) | 3 (27.3) | – | 2 (18.2) |
| Tomita et al. [26] | – | – | 11 (26.2) | 29 (69.0)f | 31 (73.8)g | 26 (61.9) | 13 (31.0) | – | – | 34 (81.0) | 24 (57.1) | – | 32 (76.2) |
Anti-ENA- Anti-Extractable Nuclear Antigen; ANA- Anti-nuclear Antibody; ESR- Erythrocyte Sedimentation Rate; LSG FS- Labial Salivary Gland Focal Score; RF- Rheumatoid Factor
a<0.1 ml/min
bLSG FS >1
cLSG FS > 0
dCriteria unknown
e<0.02 ml/min
fGrade III/IV Greenspan Criteria
gStage III/IV Rubin and Holt Criteria