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. 2017 Sep 12;7:11352. doi: 10.1038/s41598-017-11872-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Brain activation in the naturalistic smoking experiment, from a group mean analysis of 10 healthy smokers, including physiological noise modelling. Top row: axial slices. Bottom row: (from left) coronal slice, sagittal slice, and a 3D rendered image. The pattern of activation is broadly similar to the cued experiment, but somewhat less robust, and less widespread. Statistical maps are shown thresholded at Z > 2.3, p < 0.05 (cluster corrected for multiple comparisons) and neurological convention is used (L = Left, R = Right). Background anatomical image is a high-resolution version of the MNI152 T1 anatomical template.