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. 2017 Sep 8;8:469. doi: 10.3389/fneur.2017.00469

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Copyright © 2017 Vlaskamp, Poil, Jansen, Linkenkaer-Hansen, Durston, Oranje and Bruining.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of bumetanide on behavior. (A) Total score of the social responsiveness scale is decreased by treatment with bumetanide, the effect is removed at washout. (B) Irritability, as measured by the Abberant behavior checklist subscale, is markedly decreased by bumetanide treatment. At washout, irritability increases again. (C) Repetitive behavior is decreased by bumetanide treatment, as indicated by total score on the repetitive behavior scale-revised (RBS-R). Washout again removes this effect. (D) Similarly, sensory behavior as measured by Sensory Profile subscales improves during 3 and 6 months of bumetanide. Again, washout reverses the effect.