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. 2017 Sep 8;8:469. doi: 10.3389/fneur.2017.00469

Figure 2.

Figure 2

Effect of bumetanide on event-related potentials and resting-state EEG. (A) T/C ratio illustrating sensory gating (as measured by the P50 suppression paradigm) is increased (lower T/C) after 3 and 6 months of bumetanide treatment. Washout decreases sensory gating again. (B) Average detrended fluctuation analysis (DFA) exponents at different measurement time points (median across all channels) in the extended 6–13 Hz long-range temporal correlations (DFA exponents) are strengthened after 6 months bumetanide treatment. (C) Mismatch negativity for frequency (C1), duration (C2), and frequency-duration (C3) deviant. Frequency MMN amplitude increases after 6 months treatment, duration, and frequency-duration MMN amplitude show a decrease after 6-month treatment. Washout removes this effect. Gray areas represent normal range, ±1 SD from healthy population as in Rydkjaer et al. (19). Note: for duration MMN, normal range goes up to −11.98 μV.