Figure 1.

Lack of iNKT aggravates Salmonella enterocolitis and Salmonella-induced ReA. Wild type and Jα18^−/− KO BALB/c mice pretreated with 20 mg of streptomycin received 3–4 × 10³ CFU of Salmonella enterica intragastrically. Samples were taken 5 days after bacterial inoculation. Representative HE sections of intestine (A–D) and knee joint (E–H). Uninfected wild type mice, Control group (D,H); infected wild type mice, EC group, (A,E); infected KO mice, KO EC group (B,F); infected wild type mice treated with anti-CD1d mAb, anti-CD1d EC group (C,G). Scale bar 100 m. Arrows indicate synovial membrane. Differences in intestinal damage scores (I). Differences in joint damage scores (J). ^*Significant differences (p < 0.05). NS, no significant differences. Data were collected from three independent experiments. No differences in histology scores were found between uninfected KO mice or uninfected WT mice treated with anti-CD1d and Control mice.