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. 2017 Sep 8;7:397. doi: 10.3389/fcimb.2017.00397

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Copyright © 2017 Allgood, Romero Dueñas, Noll, Pike, Lein and Neunuebel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AnkX interacts with phosphoinositide lipids via its C-terminal region. (A) Schematic of lipids spotted on the phosphoinositide strip (LPA, lysophosphatidic acid; LPC, lysophosphocholine; PtdIns, phosphatidylinositol; PE, phosphatidylethanolamine; PC, phosphatidylcholine; SIP, sphingosine-1-phosphate; P, phosphate; P2, biphosphate; P3, triphosphate; PA, phosphatidic acid; PS, phosphatidylserine). (B) Protein-lipid overlay assay reveals that a C-terminal fragment of AnkX preferentially binds PI(3)P and PI(4)P. Untagged full-length AnkX was detected with an AnkX antibody and a GST antibody was used to detect the GST-tagged truncated versions of AnkX.