Fig. 3.

The distribution of emergence times from anesthesia for the combination of forskolin and preladenant was very similar to that of caffeine at 75 mg/kg. Plotted is the distribution of emergence from isoflurane anesthesia times. Left: 2 control distributions. Right: the 2 test distributions. Note that the control distribution for caffeine (■) employed a saline injection, while that for forskolin and preladenant (●) employed a DMSO injection; waking times were similar for rats injected with either saline or DMSO. Similarly, waking times were similar for rats injected with either a high dose of caffeine (♦, 75 mg/kg) or with both preladenant and forskolin (▼).