Table 2.

Changes in white matter volume and DTI metrics in the frontal regions of patients with pediatric medulloblastoma tumors and healthy controls

Regional Metric	Left Anterior Frontal Region				Right Anterior Frontal Region
	Baseline		Change over Time		Baseline		Change over Time
	P-value a	Dir b	P-value a	Dir b	P-value a	Dir b	P-value a	Dir b
WMv	ns	—	<0.001	P < C	ns	—	<0.001	P < C
FA	<0.001	P < C	<0.001	P > C	<0.001	P < C	0.004	P > C
AX	<0.001	P < C	0.001	P < C	<0.001	P < C	0.001	P < C
RAD	ns	—	<0.001	P < C	0.026	P > C	<0.001	P < C

Abbreviations: AX, axial diffusivity; C, control group; Dir, direction; DTI, diffusion tensor imaging; FA, fractional anisotropy; ns, not significant; P, patient group; RAD, radial diffusivity, WMv, white matter volume.

^aThe likelihood ratio test was used to compare the groups, and P < 0.05 was considered statistically significant.

^bDirection indicates which group (patients vs controls) had the higher value for that specific metric.