Table 3.

Comparison of changes in white matter volume and DTI metrics of patients with average- or high-risk pediatric medulloblastoma tumors and those in healthy controls

Regional Metric	Baseline				Change over Time
	All Groups		AR vs. HR		All Groups		AR vs. HR
	P-value a	Dir b	P-value a	Dir b	P-value a	Dir b	P-value a	Dir b
antL
WMv	ns	—	—	—	<0.001	P < C	ns	—
FA	<0.001	P < C	0.041	HR < AR	0.001	P > C	ns	—
AX	<0.001	P < C	ns	—	0.003	P < C	ns	—
RAD	ns	—	—	—	<0.001	P < C	ns	—
antR
WMv	ns	—	—	—	<0.001	P < C	ns	—
FA	<0.001	P < C	0.038	HR < AR	0.017	P > C	ns	—
AX	<0.001	P < C	ns	—	0.002	P < C	ns	—
RAD	0.019	P > C	ns	—	<0.001	P < C	ns	—

Abbreviations: antL, left anterior frontal region; antR, right anterior frontal region; AR, average-risk group; AX, axial diffusivity; C, control group; Dir, direction; DTI, diffusion tensor imaging; FA, fractional anisotropy; HR, high-risk group; ns, not significant; P, patient group; RAD, radial diffusivity, WMv, white matter volume.

^aThe likelihood ratio test was used to compare all 3 groups, and the Wald test was used to compare the average-risk vs high-risk groups. P < 0.05 was considered a statistically significant change.

^bDirection indicates which group had the higher value for that specific metric.