Table 4.
TBSS analysis of white matter tracts in patients with pediatric medulloblastoma tumors and healthy controls
| Brain Region | Patients > Controls a | Patients < Controls b | ||
|---|---|---|---|---|
| Pixel Count | % in Atlas c | Pixel Count | % in Atlas c | |
| Corpus callosum | 919 | 22.9 | 40 | 4.3 |
| Corticospinal tract | 19 | 0.5 | 109 | 11.6 |
| Medial lemniscus | 29 | 0.7 | 10 | 1.1 |
| Cerebellar peduncle | 284 | 7.1 | 296 | 31.5 |
| Cerebral peduncle | 220 | 5.5 | 15 | 1.6 |
| Internal capsule | 374 | 9.3 | 133 | 14.2 |
| Corona radiata | 1455 | 36.2 | 62 | 6.6 |
| Posterior thalamic radiation | 203 | 5.0 | 1 | 0.1 |
| Sagittal stratum | 19 | 0.5 | 15 | 1.6 |
| External capsule | 268 | 6.7 | 45 | 4.8 |
| Cingulum | 13 | 0.3 | 167 | 17.8 |
| Fornix | 15 | 0.4 | 14 | 1.5 |
| Superior longitudinal fasciculus | 181 | 4.5 | 31 | 3.3 |
| Superior fronto-occipital fasciculus | 12 | 0.3 | 0 | 0.0 |
| Uncinate fasciculus | 8 | 0.2 | 1 | 0.1 |
| Tapetum | 1 | 0.0 | 0 | 0.0 |
aVoxels where the change in FA over time is greater in patients than in controls represent recovery of the damaged white matter tracts and bundles.
bVoxels where the change in FA over time is smaller in patients than in controls represent damaged white matter tracts and bundles that are not recovering from damage.
cThe JHU-ICBM-DTI-81 WM Atlas23 provides information about the major white matter tracts and bundles, but it is not inclusive of all the regions analyzed by the TBSS pipeline.