Table 1.
Studies investigating brain invasion in correlation with prognosis
| Year | Author | No. of Patients and WHO Grades Included | WHO Classification | Microscopic Brain Tissue | Mortality | Progression | Median Follow-up |
|---|---|---|---|---|---|---|---|
| 1970 | Crompton et al5 | 70, grades N/A | N/A | No | N/A | Trend, no statistical analyses | N/A |
| 1993 | McLean et al3 | 28 °II–III | 1993 | No | N/A | n.s. | N/A |
| 1997 | Perry et al32 | 89, grades N/A | 1993 | Yes | N/A | Correlation in UVA and MVAa after GTR | N/A |
| 1999 | Perry et al34 | 116 °I–III | N/A | N/a | N/A | Correlation in UVA and MVAa after GTR | N/A |
| 1999 | Mantle et al2 | 135 °I–III | N/A | No | N/A | Correlation in UVA and MVA | 9 y |
| 2002 | Ho et al35 | 58 °I, 25 °II | N/A | No | N/A | Correlation in UVA | 159 mo |
| 2008 | Yang et al33 | 33 °II, 41° III | 2000 | Yes | Correlation in °III tumors in UVA | Correlation in irradiated °II in MVA | 43 mo |
| 2008 | Moradi et al40 | 329 °I, 41 °II, 8 °III | 2000 | No | N/A | Correlation in UVA | N/A |
| 2009 | Lee et al39 | 43 °I, 13° II, 3 °III | 2007 | No | N/A | Correlation in UVA | 34 mo |
| 2010 | Vranic et al30 | 76 °II, 10 °III | 2000 | Yes | Correlation in UVA | Correlation in MVAa in °III tumors | 96 mo |
| 2010 | Ruiz et al16 | 208 °I, 39 °II | 2007 | No | n.s. | n.s. | 8 y |
| 2014 | Backer- Grondal et al10 | 34 °I, 33°II | 2007 | Yes | n.s. | n.s. | >8 y |
| 2014 | Pizem et al4 | 233 °I, 51 °II, 10 °III | 2000 | Yes | N/A | Correlation in UVA | 51 mo |
| 2014 | Sun et al37 | 151 °II after GTR | 2007 | No | N/A | Correlation in UVA and MVAa | 45 mo |
| 2014 | Sun et al36 | 210 °II after STR | 2007 | No | N/A | n.s. | 67 mo |
| 2015 | Klinger et al31 | 45 °II | 2000 + 2007 | No | N/A | n.s. | 65 mo |
| 2015 | Yoon et al60 | 158 °II | 2000 | No | n.s. | Correlation in UV | 32 mo |
| 2015 | Sun et al48 | 50 °II | 2007 | Yes | N/A | Correlation in UVA and MVAa | 86 mo |
| 2016 | Spille et al45 | 401 °I, 60 °II, 6 °III | 2007 | No | n.s. | Correlation in UVA and only after GTR | 91 mo |
| 2016 | Telegu et al49 | 194 °I, 24 °II, 6 °III | 2007 | No | N/A | n.s. | N/A |
| 2016 | Baumgarten et al79 | 229 °II | 2016 | No | n.s. | n.s | 22 mo |
Abbreviations: N/A = not applicable; n.s. = not significant; GTR = gross total resection; UVA = univariate analyses; MVA = multivariate analyses.
aIncluding one or more further histopathological features of atypia. Varying WHO classifications, grades of included tumors, and follow-up periods were used within the included studies. However, most studies report correlations with tumor recurrence, while increased mortality in brain invasive meningiomas is rarely reported.