Table 2.
Univariate analysis of IDH wild-type lower-grade gliomas
| All IDH Wild-Type Tumors | Grade II | Grade III | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables | n | Median OS, y | HR (95% CI) | P | n | Median OS, y | P | n | Median OS, y | P |
| Age a | 142 | 1.05 (1.03–1.06)* | <0.001 | 72 | 1.06 (1.03–1.08)b | <0.0001 | 70 | 1.02 (1.00–1.04)b | 0.072 | |
| Gender | ||||||||||
| Male | 83 | 1.78 | 1 | 36 | 8.4 | 47 | 1.23 | |||
| Female | 59 | 3.42 | 0.71 (0.46–1.08) | 0.707 | 36 | 6.93 | 0.61 | 23 | 1.62 | 0.07 |
| Histologic Type | ||||||||||
| Oligodendroglioma | 15 | 7.63 | 1 | 8 | 7.63 | 7 | 3.5 | |||
| Oligoastrocytoma | 19 | 3.1 | 2.24 (0.80–6.46) | 13 | NR | 6 | 0.5 | |||
| Astrocytoma | 108 | 1.92 | 3.06 (1.24–7.58)* | 0.016 | 51 | 6.9 | 0.256 | 57 | 1.18 | 0.021 |
| Histologic Grade | ||||||||||
| II | 72 | 8.4 | 1 | |||||||
| III | 70 | 1.32 | 4.10 (2.58–6.54)* | <0.001 | ||||||
| Total Resection | ||||||||||
| Yes | 62 | 2.86 | 1 | 27 | NR | 35 | 1.78 | |||
| No | 52 | 1.55 | 1.54 (0.97–2.43) | 0.066 | 32 | 3.9 | 0.057 | 20 | 0.4 | 0.002 |
| Tumor Location | ||||||||||
| Nonmidline | 107 | 2.83 | 1 | 57 | 8.4 | 51 | 1.32 | |||
| Midline | 34 | 1.55 | 1.56 (0.99–2.47) | 0.06 | 15 | 4.4 | 0.228 | 19 | 1.09 | 0.387 |
| EGFR | ||||||||||
| Non-amp | 107 | 2.67 | 1 | 51 | NR | 57 | 1.62 | |||
| Amp | 18 | 1.03 | 2.31 (1.30–4.10) * | 0.004 | 8 | 0.82 | <0.0001 | 10 | 1.03 | 0.63 |
| TERT promoter | ||||||||||
| wt | 98 | 3 | 1 | 53 | 10.65 | 45 | 1.55 | |||
| mut | 35 | 1.32 | 2.44 (1.53–3.87)* | <0.001 | 14 | 1.76 | 0.0003 | 21 | 1.05 | 0.18 |
| H3F3A | ||||||||||
| wt | 116 | 2.24 | 1 | 54 | 8.4 | 62 | 1.32 | |||
| K27M | 10 | 0.5 | 2.25 (1.16–4.36)* | 0.016 | 5 | 2.83 | 0.007 | 5 | 0.5 | 0.03 |
| BRAF | ||||||||||
| wt | 114 | 2.43 | 1 | 55 | 8.4 | 59 | 1.52 | |||
| V600E | 10 | 10.65 | 0.46 (0.17–1.28) | 0.139 | 6 | NR | 0.355 | 4 | 1.85 | 0.657 |
| MYB | ||||||||||
| Non-amp | 83 | 2.57 | 1 | 45 | 8.4 | 38 | 1.17 | |||
| Amp | 29 | 2.58 | 0.88 (0.50–1.53) | 0.64 | 15 | NR | 0.518 | 14 | 1.55 | 0.54 |
aAge is a continuous variable; bhazard ratio and 95% CI shown for age; n, number of cases with data available; wt, wild-type; mut, mutant; amp, amplified; *denotes P < 0.05.