Table 3.
Multivariable analysis of IDH wild-type lower-grade gliomas
| Variables | HR (95% CI) | P |
|---|---|---|
| Age a | 1.03 (1.005–1.06)* | 0.02 |
| Histologic Type | ||
| Oligodendroglioma | 1 | |
| Oligoastrocytoma | 1.08 (0.24–4.93) | 0.923 |
| Astrocytoma | 0.90 (0.26–3.07) | 0.86 |
| Histologic Grade | ||
| II | 1 | |
| III | 9.32 (3.94–22.0)* | <0.001 |
| Total Resection | ||
| Yes | 1 | |
| No | 2.42 (1.31–4.48)* | 0.005 |
| Tumor Location | ||
| Nonmidline | 1 | |
| Midline | 1.21 (0.57–2.60) | 0.621 |
| H3F3A | ||
| wt | 1 | |
| K27M | 4.30 (1.56–11.8)* | 0.005 |
| EGFR | ||
| Non-amp | 1 | |
| Amp | 3.77 (1.08–13.1)* | 0.037 |
| TERT promoter | ||
| wt | 1 | |
| mut | 1.53 (0.73–3.18) | 0.259 |
| EGFR by TERT promoter interaction | 0.79 (0.17–3.64) | 0.766 |
aAge is a continuous variable; wt, wild-type; mut, mutant; amp, amplified; *denotes P < 0.05.