Table 2. MMP-2 (–1306 C/T) genotype frequency in patients with AMD with soft and hard drusen, in geographic atrophy and in the control group.

Gene	Genotype/allele	Control group n=526	PHWE	AMD group (soft drusen) n=147	PHWE	AMD group (hard drusen) n=143	PHWE	AMD group (geographic atrophy) n=34	PHWE
MMP-2 (–1306) Rs2285053	Genotype
	C/C	289 (54.94)1	0.4	79 (53.74)2	0.22	95 (66.43)1,2	0.8	17 (50.00)	0.54
	C/T	198 (37.64)		56 (38.10)		43 (30.07)		13 (38.24)
	T/T	39 (7.41)		12 (8.16)		5 (3.50)		4 (11.76)
	Allele
	C	0.72		0.7		0.81		0.69
	T	0.28		0.3		0.19		0.31

P_HWE: Significance level by Hardy-Weinberg equilibrium. ¹P=0.017; ²P=0.03.

n (%)