Table 1. Pharmacokinetic parameters of simvastatin in retina.
| Parameters | T1/2 (h) | Cmax (pmol) | Cmax (ng, per g of retina) | Tmax (h) | AUCall (h x µg/mL) | MRT (h) | CL (mL/h) |
| NCA 200 µmol/L | 2.37 | 347.86 | 105.41 | 1 | 1429.3 | 2.38 | 0.14 |
| 1CM 200 µmol/L | 1.92 | 506.37 | 153.45 | 0 | 1400.6 | 2.77 | 0.14 |
| NCA 50 µmol/L | 2.31 | 55.04 | 16.68 | 1 | 256.0 | 2.69 | 0.19 |
| 1CM 50 µmol/L | 2.41 | 75.23 | 22.80 | 0 | 261.7 | 3.48 | 0.19 |
NCA: Non-compartmental analysis; 1CM: 1-compartment modeling; Cmax: Observed/predicted max quantity; Tmax: Time to Cmax; AUC: Area under the curve; MRT: Mean residence time; CL: Clearance. Mean wet weight of mouse retina=3.3 mg; data taken from Cerani et al[47].