Table 1.

Hepatic metabolism of ¹¹C-methionine in pigs

	K met (mL plasma/mL liver tissue/min)		k loss (min-1)		F flux (µmol methionine/mL liver tissue/min)		R prot (kBq/mL plasma/min)
Procedure	Lap	Pneu	Lap	Pneu	Lap	Pneu	Lap	Pneu
Pig 1 and 2	0.231	0.216	0.0037	0.0056	4.34	1.43	0.085	0.049
Pig 3 and 4	0.122	0.411	0.0028	0.0119	1.80	7.72	0.037	0.083
Pig 5 and 6	0.290	0.175	0.0070	0.0068	5.53	2.98	0.061	0.008
Pig 7 and 8	0.338	0.124	0.0090	0.0043	n.d.	2.02	0.055	0.038
Pig 9 and 10	0.086	0.179	0.0033	0.0011	1.81	4.41	0.021	0.045
Pig 11	0.163		0.0038		3.89		0.051
Mean	0.205	0.222	0.0049	0.0059	3.47	3.71	0.052	0.045
P	0.81		0.62		0.86		0.64
Average mean (n = 11)	0.212		0.0054		3.59		0.048

Lap, laparotomy; Pneu, pneumoperitoneum; K _met, hepatic metabolic clearance of ¹¹C-methionine; k _loss, rate constant of secretion of ¹¹C-protein and ¹¹C-metabolites from liver tissue to blood; F _flux, flux of methionine from plasma to liver tissue; R _prot, rate of appearance of ¹¹C-protein in plasma; n.d., not determined.