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. 2017 Sep 12;8(5):e01183-17. doi: 10.1128/mBio.01183-17

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Copyright © 2017 Botella et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Composition of M. tuberculosis peptidoglycan and structures of the fluorescent d-alanine analogs that allow its visualization. (A) Schematic representation of M. tuberculosis peptidoglycan (PG). M. tuberculosis’s PG is composed of strands of a repeating unit of the disaccharide N-acetyl-glucosamine (NAG) and N-acetyl-muramic acid (NAM). The strands are linked by peptide chains composed of l-alanine (l-Ala), d-iso-glutamine (d-iso-Glu, a product of amidation of d-Glu), meso-diaminopimelic acid (meso-DAP), and d-alanine (d-Ala). (B) Chemical structures of the fluorescent d-alanine analogs, HADA and NADA. Ex., excitation; Em., emission.