Table 1. Comparison of PSEN-1 TT Genotypic and T allelic frequencies among different groups of mothers of DS children and control mothers of karyotypically normal children.
| Comparisons | TT genotypic frequency | P value of Chi–squared test | T allelic frequency | P value of Chi–squared test | ||
|---|---|---|---|---|---|---|
| Case | Control | Case | Control | |||
| Case mothers (N = 170) vs. | 55.29% | 48.92% | 0.36 | 72.35% | 68.55% | 0.65 |
| Control mothers (N = 186) | ||||||
| MI case mothers (N = 106) vs. | 49.06% | 48.92% | 0.98 | 68.39% | 68.55% | 0.98 |
| Control mothers (N = 186) | ||||||
| MII case mothers (N = 64) vs. | 65.63% | 48.92% | 0.02 | 78.91% | 68.55% | 0.21 |
| Control mothers (N = 186) | ||||||
| MII case mothers (N = 64) vs. | 65.63% | 49.06% | 0.02 | 78.91% | 68.39% | 0.20 |
| MI case mothers (N = 106) | ||||||
| Young case mothers (N = 86) vs. | 55.81% | 44.09% | 0.08 | 73.26% | 63.98% | 0.25 |
| Young control mothers (N = 93) | ||||||
| Old case mothers (N = 84) vs. | 54.76% | 53.76% | 0.89 | 71.43% | 73.12% | 0.84 |
| Old control mothers (N = 93) | ||||||
| MI - young case mothers (N = 53) vs. | 49.06% | 44.09% | 0.45 | 68.87% | 63.98% | 0.54 |
| Young control mothers (N = 93) | ||||||
| MI - old case mothers (N = 53) vs. | 49.06% | 53.76% | 0.52 | 67.92% | 73.12% | 0.54 |
| Old control mothers (N = 93) | ||||||
| MII - young case mothers (N = 33) vs. Young control mothers (N = 93) | 66.67% | 44.09% | 0.0007 | 80.3% | 63.98% | 0.04 |
| MII - old case mothers (N = 31) vs. | 64.52% | 53.76% | 0.14 | 77.42% | 73.12% | 0.62 |
| Old control mothers (N = 93) | ||||||
| APOE ε4 positive - young case mothers (N = 30) vs. APOE ε4 positive - young control mothers (N = 22) | 66.67% | 45.45% | 0.002 | 80% | 65.91% | 0.08 |
| APOE ε4 positive - old case mothers | 52.38% | 55% | 0.72 | 69.05% | 72.5% | 0.69 |
| (N = 21) vs. APOE ε4 positive - old control mothers (N = 20) | ||||||
| APOE ε4 negative - young case mothers (N = 56) vs. APOE ε4 negative - young control mothers (N = 71) | 50% | 43.66% | 0.34 | 69.64% | 63.38% | 0.43 |
| APOE ε4 negative - old case mothers | 55.56% | 53.42% | 0.77 | 72.22% | 73.29% | 0.90 |
| (N = 63) vs. APOE ε4 negative - old control mothers (N = 73) | ||||||
| APOE ε4 positive - MI - young case mothers (N = 16) vs. APOE ε4 positive - young control mothers (N = 22) | 43.75% | 45.45% | 0.80 | 65.62% | 65.91% | 0.97 |
| APOE ε4 positive - MI - old case mothers (N = 13) vs. APOE ε4 positive - old control mothers (N = 20) | 46.15% | 55% | 0.23 | 65.38% | 72.5% | 0.40 |
| APOE ε4 negative - MI - young case mothers (N = 37) vs. APOE ε4 negative - young control mothers (N = 71) | 51.35% | 43.66% | 0.24 | 70.27% | 63.38% | 0.39 |
| APOE ε4 negative - MI - old case mothers (N = 40) vs. APOE ε4 negative - old control mothers (N = 73) | 50% | 53.42% | 0.64 | 68.75% | 73.29% | 0.59 |
| APOE ε4 positive - MII - young case mothers (N = 14) vs. APOE ε4 positive - young control mothers (N = 22) | 92.86% | 45.45% | <0.0001 | 96.43% | 65.91% | 0.0002 |
| APOE ε4 positive - MII - old case mothers (N = 8) vs. APOE ε4 positive - old control mothers (N = 20) | 62.5% | 55% | 0.31 | 75% | 72.5% | 0.77 |
| APOE ε4 negative - MII - young case mothers (N = 19) vs. APOE ε4 negative - young control mothers (N = 71) | 47.37% | 43.66% | 0.57 | 68.42% | 63.38% | 0.53 |
| APOE ε4 negative - MII - old case mothers (N = 23) vs. APOE ε4 negative - old control mothers (N = 73) | 65.22% | 53.42% | 0.11 | 78.26% | 73.29% | 0.56 |
| APOE ε4 positive - MII case mothers | 81.82% | 44.83% | <0.0001 | 88.64% | 65.52% | 0.004 |
| (N = 22) vs. APOE ε4 positive - MI case mothers (N = 29) | ||||||
Young mothers, < 35 yrs of age; Old mothers, < 35 yrs of age
MI, nondisjunction at meiotic division I; MII, nondisjunction at meiotic division II