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. 2017 Aug 25;7(8):e593. doi: 10.1038/bcj.2017.74

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Morphological analysis of various blood cell types harvested from the KM and peripheral blood of Tg(spi1:SOX4-EGFP) zebrafish at indicated age. Tg(spi1:SOX4-EGFP) KM smears showed myeloid hyperplasia with increased production of myeloblasts in an age-dependent manner (a) and their peripheral blood smears showed immature myeloid cells (b). Conversely, wild-type fish showed normal hematopoiesis with adequate maturation (magnification: × 1000).