Table 1. Multivariate analysis (Cox regression) of SOX4 expression on the overall survival and disease-free survival.

Variables	Overall survival				Disease-free survival
		95% CI				95% CI
	RR	Lower	Upper	P value	RR	Lower	Upper	P value
Agea	1.023	1.002	1.044	0.034	1.012	0.994	1.029	0.203
WBCb	1.004	1.000	1.007	0.029	1.004	1.001	1.006	0.012
Karyotypec	3.038	1.188	7.771	0.020	2.127	1.105	4.096	0.024
NPM1/FLT3-ITDd	1.197	0.510	2.811	0.680	1.345	0.651	2.778	0.423
High SOX4e	1.924	1.020	3.628	0.043	1.663	0.983	2.813	0.058

Abbreviations: CI, confidence interval; RR, relative risk; WBC, white blood cell.

^aThe risk by 1 year older in age.

^bThe risk by 1000/μl increase in WBC.

^cUnfavorable cytogenetics vs others.

^dNPM1^mut/FLT3-ITD^neg vs other subtypes.

^eHigh SOX4 expression vs low SOX4 expression.