Figure 6.

Overexpression of miRs-143 or -145 profoundly perturbates the transcriptome of NMuMG cells. (a,b) Venn diagrams representing the overlap between MREdictor predicted targets of miR-143 (a) or miR-145 (b), and the genes commonly modulated by the overexpressed miRNAs in NMuMG cells. Note statistically significant enrichment only among downregulated genes. (c–f) Whole lysates from the indicated cells were analyzed by western blot. (g) Model explaining the EMT phenotype triggered by overexpression of either microRNA