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. 2017 Aug 11;7(14):3415–3431. doi: 10.7150/thno.20861

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Brusatol induces cancer cell death in vitro under hypoxic conditions. (A and B) Effects of brusatol on clonogenic cell death in RKO (A) and HCT116 (B) cells under hypoxia. (C and D) Effects of PHDs on brusatol-induced clonogenic cell death in RKO (C) and HCT116 (D) cells under hypoxia. (E and F) Effects of intracellular ferrous iron on brusatol-induced clonogenic cell death in RKO (E) and HCT116 (F) cells under hypoxia. (G and H) Effects of c-Myc on brusatol-induced clonogenic cell death in RKO (G) and HCT116 (H) cells under hypoxia. Data are presented as means ± SD (*P < 0.05, ***P < 0.001, ****P < 0.0001; ANOVA).