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Artificial thymus generated from FOXN1-reprogrammed fibroblasts. (A) Schematic of the procedure to show in vivo grafting assay. (B) Summary of recovered grafts after various treatment as indicated. (C) H&E staining (left), and pan-cytokeratin (right) staining of the iTEC-derived kidney graft, indicating that FOXN1-induced TECs (iTECs) established a complete, fully organized and functional thymus. Reprinted with permission from ref. 142 Copyright 2014 Nature Publishing Group.
