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. 2017 Aug 22;7(14):3585–3594. doi: 10.7150/thno.21471

Figure 2.

Figure 2

Mutation burden by subgroups of PD-L1/CD8A/CYT expression across TCGA cancer types. Boxplot distributions of log 2-transformed values of the number of somatic mutations between subgroups of PD-L1/CD8A/CYT expression, as defined by RPART cut-off or median value, according to TCGA cancer types (A-N). For some cancer types, the number of mutations differ significantly in certain RPART subgroups: in PD-L1 subgroups for BLCA, BRCA, CESC, COAD, KIRC, LIHC, LUAD, SKCM, and STAD; in CD8A subgroups for BLCA, CESC, COAD, KIRC, LIHC, and LUAD; and in CYT subgroups for BLCA, BRCA, CESC, COAD, LUAD, SKCM, and STAD. P values are calculated by Wilcoxon rank-sum test (*P < 0.05, **P < 0.001). RPART, Recursive Partitioning and Regression Trees.