Table 2.
HLA-DRB1 allele carrier frequency in the patients with AOSD and in controls
| Cases (n = 96) | Controls (n = 1026) | P | OR | Pc | 95% CI | |
|---|---|---|---|---|---|---|
| DRB1*01:01 | 9 (9.4) | 110 (10.7) | 0.8622 | 0.86 | NS | (0.42–1.76) |
| DRB1*03:01 | 0 (0.0) | 3 (0.3) | 1.0000 | 1.52 | NS | (0.08–29.55) |
| DRB1*04:01 | 0 (0.0) | 22 (2.1) | 0.2486 | 0.23 | NS | (0.01–3.84) |
| DRB1*04:03 | 4 (4.2) | 47 (4.6) | 1.0000 | 0.91 | NS | (0.32–2.57) |
| DRB1*04:04 | 0 (0.0) | 4 (0.4) | 1.0000 | 1.18 | NS | (0.06–22.03) |
| DRB1*04:05 | 21 (21.9) | 243 (23.7) | 0.8014 | 0.90 | NS | (0.54–1.49) |
| DRB1*04:06 | 2 (2.1) | 76 (7.4) | 0.0562 | 0.27 | NS | (0.06–1.10) |
| DRB1*04:07 | 0 (0.0) | 15 (1.5) | 0.6313 | 0.34 | NS | (0.02–5.70) |
| DRB1*04:10 | 4 (4.2) | 32 (3.1) | 0.5413 | 1.35 | NS | (0.47–3.90) |
| DRB1*07:01 | 0 (0.0) | 9 (0.9) | 1.0000 | 0.55 | NS | (0.03–9.61) |
| DRB1*08:02 | 13 (13.5) | 72 (7.0) | 0.0403 | 2.08 | NS | (1.10–3.90) |
| DRB1*08:03 | 16 (16.7) | 153 (14.9) | 0.6544 | 1.14 | NS | (0.65–2.01) |
| DRB1*08:09 | 0 (0.0) | 2 (0.2) | 1.0000 | 2.12 | NS | (0.10–44.55) |
| DRB1*09:01 | 11 (11.5) | 280 (27.3) | 0.0004 | 0.34 | 0.0110 | (0.18–0.66) |
| DRB1*10:01 | 0 (0.0) | 5 (0.5) | 1.0000 | 0.96 | NS | (0.05–17.54) |
| DRB1*11:01 | 6 (6.3) | 41 (4.0) | 0.2837 | 1.60 | NS | (0.66–3.87) |
| DRB1*12:01 | 16 (16.7) | 75 (7.3) | 0.0031 | 2.54 | 0.0896 | (1.41–4.56) |
| DRB1*12:02 | 8 (8.3) | 37 (3.6) | 0.0488 | 2.43 | NS | (1.10–5.38) |
| DRB1*13:01 | 2 (2.1) | 8 (0.8) | 0.2082 | 2.71 | NS | (0.57–12.93) |
| DRB1*13:02 | 5 (5.2) | 163 (15.9) | 0.0040 | 0.29 | 0.1150 | (0.12–0.73) |
| DRB1*14:03 | 7 (7.3) | 44 (4.3) | 0.1941 | 1.76 | NS | (0.77–4.01) |
| DRB1*14:04 | 0 (0.0) | 4 (0.4) | 1.0000 | 1.18 | NS | (0.06–22.03) |
| DRB1*14:05 | 6 (6.3) | 40 (3.9) | 0.2758 | 1.64 | NS | (0.68–3.98) |
| DRB1*14:06 | 2 (2.1) | 29 (2.8) | 1.0000 | 0.73 | NS | (0.17–3.11) |
| DRB1*14:07 | 0 (0.0) | 2 (0.2) | 1.0000 | 2.12 | NS | (0.10–44.55) |
| DRB1*14:54 | 6 (6.3) | 58 (5.7) | 0.8168 | 1.11 | NS | (0.47–2.65) |
| DRB1*15:01 | 31 (32.3) | 139 (13.5) | 8.60 × 10-6 | 3.04 | 0.0002 | (1.91–4.84) |
| DRB1*15:02 | 18 (18.8) | 224 (21.8) | 0.5197 | 0.83 | NS | (0.48–1.41) |
| DRB1*16:02 | 0 (0.0) | 18 (1.8) | 0.3919 | 0.28 | NS | (0.02–4.72) |
| DR5(*11, *12) | 28 (29.2) | 151 (14.7) | 0.0006 | 2.39 | (1.49–3.83) |
Allele carrier frequencies are shown in parentheses (%). Association was tested by Fisher’s exact test using 2 × 2 contingency tables under the dominant model. AOSD adult onset Still’s disease, OR odds ratio, CI confidence interval, Pc corrected p value, NS not significant