Table 1.
Anatomic Properties of the Experimental Muscles
| Muscle | Strain | n | Body Weight (g) | Muscle Weight (mg) | Lo (mm) | CSA (mm2) |
|---|---|---|---|---|---|---|
| EDL | ||||||
| DBA/2J | 10 | 28.22 ± 0.48a | 10.36 ± 0.32a | 13.08 ± 0.08a | 1.71 ± 0.05a | |
| DBA/2J-mdx | 8 | 24.50 ± 0.58 | 7.31 ± 0.25b | 13.70 ± 0.15 | 1.15 ± 0.04b | |
| DBA/2J-mdx treated | 5 | 25.00 ± 0.76 | 8.80 ± 0.24 | 13.98 ± 0.07 | 1.35 ± 0.03 | |
| TA | ||||||
| DBA/2J | 5 | 27.28 ± 1.11 | 40.22 ± 1.16 | 14.67 ± 0.05 | 4.33 ± 0.12 | |
| DBA/2J-mdx | 8 | 24.41 ± 0.52 | 37.38 ± 1.43 | 14.78 ± 0.17b | 3.99 ± 0.13 | |
| DBA/2J-mdx treated | 5 | 25.00 ± 0.76 | 38.12 ± 1.00 | 14.14 ± 0.07 | 4.25 ± 0.11 | |
Data are presented as means ± SEM. CSA, cross-sectional area; EDL, extensor digitorum longus; Lo, optimal muscle length; TA, tibialis anterior.
a
Significantly different from both untreated and AAV-treated DBA/2J-mdx mice.
b
Significantly different from DBA/2J and AAV-treated DBA/2J-mdx.