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. Author manuscript; available in PMC: 2017 Sep 13.
Published in final edited form as: Nat Prod Rep. 2011 May 9;28(7):1229–1260. doi: 10.1039/c0np00013b

Scheme 4.

Scheme 4

Proton-mediated isomerization of clathrodin/oroidin and further polycyclizations: alternative biosynthetic hypothesis for the formation of dibromophakellin and dibromoagelaspongin