Figure 2.

The number of dopaminergic periglomerular neurons (TH+PG cells) is decreased in Tg2576 mice compared with age-matched WT mice. (a) Depictions of coronal sections through the OB. Single glomerulus and H&E staining depicting the glomerulus with dopaminergic periglomerular neurons (TH (+) PG cells) are represented. Reduced activity between OSNs and mitral cells, or sensory deprivation, may result in profound decreases in TH expression. (b) Stereological analysis of TH (+) PG cells/total PG cells in the OB of WT versus Tg of 6- and 14-month-old. (c) Depictions of coronal sections through the OB with region of interest. Blue outline shading denotes the dorsal MOB. Orange outline shading denotes the ventral MOB. (d and f) Evolution of the TH (+) PG cells/total PG cells in WT versus Tg in 6-month-old (WT, n=7; Tg, n=7) (d) and 14-month-old (WT, n=9; Tg, n=8) (f). (e and g) Stereological analysis of TH+periglomerular cells/total periglomerular cells (WT control in each group) in 6-month-old (e) and 14-month-old (f) mice. All data are presented as mean±S.E.M. Scale bar=10 μm. Two-way ANOVA, using Prism software (GraphPad software), *P<0.05, **P<0.01 and ***P<0.001 denote statistical significance