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Working hypothesis of olfactory dysfunction and impairment in an AD mouse model. OE impairment and cell death occur in Tg2576 mice. In particular, the expression of Aβ oligomers is increased in the OE of Tg2576 mice compared with WT mice. In addition, the integrity of the connection between axons from the OE and dendrites in the OB is disturbed in Tg2576 mice compared with WT mice. Furthermore, dopaminergic periglomerular cells (TH+PG cells) are reduced in the glomerulus
