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. 2017 Aug 10;8(8):e2998. doi: 10.1038/cddis.2017.357

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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miR-34/449 overexpression attenuated autophagy-related fibrosis. BEAS-2B cells transfected with or without miR-34 and miR-449 mimics were treated with or without 3-MA (200 μM) for 1 h before induction with IL-13 for 72 h. (a–d) Western blot analysis of Beclin-1, LC3 and P62 and densitometric quantification of bands. Values represent the mean±S.E.M. (n=3), *P<0.05, **P<0.01, ***P<0.001 versus control. ^##P<0.01, ^###P<0.001 versus IL-13 group. (e–i) Western blot analysis of collagen I, collagen III, bFGF and α-SMA, and densitometric quantification of bands. Values represent the mean±S.E.M. (n=3), *P<0.05, **P<0.01, ***P<0.001 versus control. ^##P<0.01, ^###P<0.001 versus IL-13 group